Acute Sickle Crisis Evaluation

Acute Sickle Crisis Evaluation

Scenario: Patient is a 45 year old male presenting with acute onset of pain that began in his legs and has since spread to his lower back. The pain is rated 9/10 and described as deep, throbbing, and constant. He has had several similar episodes in the past year, usually following dehydration or infection. He denies trauma.

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Lab Pt value Normal values

Hemaglobin 8.1 13.5-17.5

Hematocrit 24 38-50

RBC 2.9 4.7-6.1

WBC 13000 4000-11000

Reticulocyte count 8% 0.5-2.5%

Total bilirubin 3.5 0.2-1.2

LDH 520 140-280

Peripheral smear Presence of sickled cells,

target cells, Howell-Jolly

bodies

Questions

  • Which genetic mutations are commonly associated with the disease?
  • Why is the patient presenting with the specific symptoms described?
  • Discuss the pathophysiological mechanisms of the disease in detail.
  • What do the blood test results tell us about the disease and disease progression?

Acute Sickle Crisis Evaluation

Acute Sickle Crisis Evaluation

Scenario: Patient is a 45 year old male presenting with acute onset of pain that began in his legs and has since spread to his lower back. The pain is rated 9/10 and described as deep, throbbing, and constant. He has had several similar episodes in the past year, usually following dehydration or infection. He denies trauma.

Lab Pt value Normal values

Hemaglobin 8.1 13.5-17.5

Hematocrit 24 38-50

RBC 2.9 4.7-6.1

WBC 13000 4000-11000

Reticulocyte count 8% 0.5-2.5%

Total bilirubin 3.5 0.2-1.2

LDH 520 140-280

Peripheral smear Presence of sickled cells,

target cells, Howell-Jolly

bodies

Questions

  • Which genetic mutations are commonly associated with the disease?
  • Why is the patient presenting with the specific symptoms described?
  • Discuss the pathophysiological mechanisms of the disease in detail.
  • What do the blood test results tell us about the disease and disease progression?

Acute Sickle Crisis Evaluation

Scenario: Patient is a 45 year old male presenting with acute onset of pain that began in his legs and has since spread to his lower back. The pain is rated 9/10 and described as deep, throbbing, and constant. He has had several similar episodes in the past year, usually following dehydration or infection. He denies trauma.

Check tips on how to complete your BSN Assignment.

Lab Pt value Normal values

Hemaglobin 8.1 13.5-17.5

Hematocrit 24 38-50

RBC 2.9 4.7-6.1

WBC 13000 4000-11000

Reticulocyte count 8% 0.5-2.5%

Total bilirubin 3.5 0.2-1.2

LDH 520 140-280

Peripheral smear Presence of sickled cells,

target cells, Howell-Jolly

bodies

Questions

  • Which genetic mutations are commonly associated with the disease?
  • Why is the patient presenting with the specific symptoms described?
  • Discuss the pathophysiological mechanisms of the disease in detail.
  • What do the blood test results tell us about the disease and disease progression?
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